USMLE Step 1 Practice Test

280 questions252 minutesDetailed explanationsInstant scoring

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About the Real USMLE Step 1 Exam

USMLE Step 1 medical licensing exam (basic sciences). A strong, blueprint-matched practice run is one of the best predictors of how you will perform on the real exam.

Our USMLE Step 1 Practice Test

Our USMLE Step 1 practice test contains 280 original questions spanning Foundational Sciences, Organ Systems, Pharmacology & Behavioral. Each question mirrors the real exam's style and difficulty and includes a detailed explanation, so every question teaches you something.

What to Expect

Foundational Sciences: Biochem, genetics, microbiology, immunology, pathology.
Organ Systems: Cardiovascular, respiratory, renal, neuro, endocrine.
Pharmacology & Behavioral: Pharmacology, behavioral science, biostatistics.

Try a Sample Question

USMLE Step 1 — Sample · medium

The rate-limiting enzyme of glycolysis is which of the following?

A Phosphofructokinase-1

B Aldolase

C Pyruvate kinase

D Hexokinase

Explanation. Phosphofructokinase-1 (PFK-1) catalyzes the committed, rate-limiting step of glycolysis and is allosterically regulated by ATP and fructose-2,6-bisphosphate. Hexokinase and pyruvate kinase are regulated but not the primary rate-limiting step, and aldolase is not a key regulatory enzyme.

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